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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48d54495a7748627507c05d8420c4f8ba5ad698d1bec2ef4bf1b3d964c239a65' 
  AND token = 'FQWvSzsD9uSeNZOCTGWFFMpfxo/0FX2EuwRIE8hsAmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}