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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e74244afdc092ca189195e887f7afeda571d43ed7f63af4153d47eec42b4b6f3' 
  AND token = 'E33YWFj0k1Uz/JIjerMhFF6TwsHCOS/wSCJoBEB8TmY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}