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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4900ea0de6a8041be4071323f3c8636cf5a9ed14a08c0c59da50529a8dedc43' 
  AND token = 'GunwP/+8mtY6zfyaM/YYQrQ6XF7ebv1fExNTfaucc2Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}