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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd9fa7f820d22e6e5810697b4047bd3da0d481d3b9f9998352187e2c502deb797' 
  AND token = 'U3dald7fSuljCixRD9Grgp35BAjXckn414QDTapFz5Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}