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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '17501ae2bdb4862db2a4f626a6319ec4de3169b9d4cf4c1efb91c58f4726f67d' 
  AND token = 'eNnJC/D7Zjeahl+A5vyNKdeEPjiHG0FpZ5ANG29yqiA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}