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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14c2d121d92bdeb00f7d532b7f41e1e45c423ebbfcfa3effa28886d378302401' 
  AND token = '0o/WqPvcd8qmf1G1F2EP2TEI3K3gQNGQAEDCvtXgFAs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}