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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f46d3be87451d4b3475e783d547d7af53a944ac023b1589c47f1e44e82ad69f' 
  AND token = '5+0oIdxMT1YF4zgx6Tc4nm7eW3Jq0LPA1JgIXXOTM2I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}