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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05f37e07b73f65d9f15867f23f1c0bb0a1b2856a4ed5a15d340e0edc6b5f5c19' 
  AND token = 'XlAM+FPlrflXMzdKf4WKMcD7sI80fmfYwv+6wlANAEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}