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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280b871813d9a222cde718c6fd1632c4bfcee7667cbc3d049c0f0301706db117' 
  AND token = '5C90fQIbr7IfD+dKEzRT38w9ZKKD/zUD/nAQY23PiHY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}