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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4043735f0570b12aa2a075e44c15e89e2f65332809260cb0e132098b583a32a6' 
  AND token = '3vOa4fLfcaHnU2F5QhMUuCMoIpb/P/bFlVSTgIgNtDY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}