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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '491339a0e32a09660ea1990e5f7046ca7f0144b19f039623ce592c2da4794b9f' 
  AND token = 'a+OI37kg4bK/4z8gCBTEsOGzQXlnzWVGvRXEln3bZK8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}