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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f37986ad4f11ce65acd07b33ea0629aa0fbfd439c3072584a544288d743b564' 
  AND token = 'bLO4Q+hWDUQ5iHo34SpHOFv50/i/HcBUI5IazW7ScK0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}