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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220b886af1b05b27d6e4531ef6b2312f490203a07bb3cf68c6504b328a756426' 
  AND token = 'eC5i4yPwL8rO3QQEzsMC2FJdGGYM4yPgWcGafmZBW44=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}