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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8e04ba8df6344e740b800bb8e89e84725fd8edf560b59647957b719c1fe0fed' 
  AND token = 'DbFsBaqnETH8obHDtqolumUcd2UeVdzEe4CMDHZqyRk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}