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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4414728e6670a48aed8d9e5a4445b8d8b48ff0e6b6d1d6ea461e612477a5942' 
  AND token = 'NIE3jT+AYoE/u8dZmid8QxWhl8ENRxPlqmspTaQpr8o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}