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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '223aa3728d49398b542207d62409643086ea779cb663f6b9c0144707e3e7df8b' 
  AND token = '+8Tm0Fbqu3dVz1wTzBZTafaj0AxgtRmtsWolwMCLFJA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}