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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f793e718b9a08c1fb7ca5b6fecd7a2b786872f1ad16b2048d5207f51ee88263' 
  AND token = 'VPDLmy2JNPVkIAedJy1jhGR8sS+VIVB5YaqfD8UVPT0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}