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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e281db787d7aec70bcf403f9c79ee2ebaa38021b2bc1b2356d6211a524a065ad' 
  AND token = 'RUgNZUQ+oDOrao+0LH0GRSeKWXoYfbrlL+vDvLrUqhA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}