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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c2c61be87d592a29a36333324abbf48f8c816a08ffb6d269501950c5b9879a82' 
  AND token = 'h6Qp+XOyoSSfuaatQF6q6MgpuAOPVe1BcBfTwPcC3eU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}