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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef9a7e5700c4cedc28caf5b367bc36f20ad8b780e53fc5e96e54657a10bca33d' 
  AND token = 'UQoHgfzg2Hr+Hxd7ZcmpyBorLWHFTlgDDZpA20bDqzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}