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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25d03e23f69e19595d98d0d5721ec2cf459e8485f8fd81af2c92ddb0b54663ff' 
  AND token = 'I1/VeGW9xpMJNDzAWKG1fq/DGa0tofoq7OxKJUVuUT4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}