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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fad43c53540d50c14bb3b67f79699944154b145c1ad8fbc314ca839c0f61f28b' 
  AND token = 'fUv0IHUd1Jns2Fu36IAt/4HBTA+xdyQtE5oxqjuNmgY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}