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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b183139d2e28d87657eef28cd050f0caf6aee0e091ddf628677b17b209af337' 
  AND token = 'wcw8W/Mj6n0OWS8e8DjIb/qYmBLHtkGmNek5x0eJvQo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}