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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ca07d80ebf9c35e00a9230d4963bc4bb298328296c4cca8a497d70c1805f2a21' 
  AND token = 'khHYx/SzEcA2BtaCyp27r8oRQ8iyQ6ucpTWyTGkGcCc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}