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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e00434c236ae3ceabeae966fd809fe081df9bc428f64db8b93f2e74d9b975438' 
  AND token = 'xHL2J/UvA8vHPXp5vlCpKqle15y1WgyWlvW0S85LqNM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}