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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45e8cbb973917c382c2308cb136ae222e1a7b4af9d9cca2b79d38f7ce167c2f5' 
  AND token = '+/q8mzWoj9jxaJl/ZNQHN6bt24I1L/4xbTKNYSf/Bl4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}