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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78c8e2a8485e38ed4ae42704ce0a1b3f903cba857ed8e23928ca7a106f87c73b' 
  AND token = 'Z4oPmbPuMLEJdzDSpVKrDVHBW7XOqzOIg4LCBrBBTOg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}