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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eff23374ffda3ebe18d5b027763404d22499d8e3ba511fc66e9859d5332e01fd' 
  AND token = 'NxwBG/Spt1nGjdjOnVPRG3HQCXPjHB8PYp5cz4EPLx0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}