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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b80f90c01952281d7134dc4e4c2fef403819ad02b2a03a1f65569a2b218f2225' 
  AND token = 'soH/FsFVLuXSQjB0a0K/B/g6ot4TTqIKQW0rVpSuYgA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}