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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22af2118c5860c7aafc057e87466bc2538090218b660af5cbde186d24c98b494' 
  AND token = 'k7pwxmJnN5ie4PmwS3QKfhU+JI3m1i3F4kCgKDBEh9o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}