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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f6eb8495a4e24d69daac89d56c599b4c5c3230b0b100c636846fd91b1992e21' 
  AND token = 'Vh+/hLzPeQv1PTYSdaGEN+Fh6faRd0Nv1UZOPYkG9HE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}