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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b85966806c6ec3ebb8664305408c9f98ff8dbe52e0d5db3ac449131b8de2bbd' 
  AND token = 'a9HMtbqaX+NDjDPdiz8+PQhKEyC8BM7htyDkAWXGLIg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}