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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de7f387cd2a43ce37705ca679019f9e2e680e8c66d34ce56453f3eb1d18b17e8' 
  AND token = 'HsR+z+nbH/sxF10Yvdw1OPD6THuhQZ2EJipX8dD87HY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}