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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42ec51ef940efc5e4b34655e824be1216477b163ae79ad1ffebdeece1d3ef978' 
  AND token = 'zq+K9V823dwZAo5KqBKAUUKyNX3DGCk0htUsVi9tyrY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}