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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f54080b206f8464c3b1c79a00941f28f79c31c03f40ed899bac5b412bf4a79f1' 
  AND token = '+GINNcQBumWkiBlHxys7gPNK2iEprMX3/XRSlq1Ygro=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}