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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f4da1f148ba3d093807f4e5988b6756e9d5a2854c5dca66ae4ec3a1089b50d2' 
  AND token = '15U/49Hd7UHsjyJgCmY/EJHRYT/lr9Jo+EfV9t28jg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}