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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c5a5d1b66564056d025bf68e0609dda479a1291447f7238f807f2baeb0a0018' 
  AND token = 'ORikoI22YBh9lc6CV4UHs/XYiMfcxde/n7RLh4VWU74=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}