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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49a09c557db6d266ad0549b7d0edbb627ef07ac1605c292d3ab6f935a6c7dab2' 
  AND token = 'Qbk+cYtTclrArE4oIlSP3MlXwRRU4w+7cvCbgC2ebNg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}