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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2cf4ad4b8fae7c3b5ba154fc86cd3497c407f27fb2825e989416a2f7b008d622' 
  AND token = 'H7+ytZ7xe+KHvjRykjNgu8jgH/2Ykcp3XaroJUk6n78=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}