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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '530e0c5ed5c81c98d84bfaca1c5ae0fb0eab9b205a6827ee09179212739c8c40' 
  AND token = 'O27XICUe2SQqjx7g/svj068HuqJwkK93QeJ9JLPPCjs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}