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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12df288daa095b94463bf0138f1e89648b1bbdcbe09640677b320c0b0e9f834d' 
  AND token = 'MQYVPgAVx/rO9uB9PxGaAy3w8738HEo+8BgUhnAjHl0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}