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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41fe64c42f2aaf24338818e555bff775280f8c661dae36ef3a6bf0fbcd927abf' 
  AND token = 'P37gVZ/xmpc+u0tTH6IpMU/LmF5r2a8UZSdJucf8Bxw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}