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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '846d82a80f732b4a732d4d11a1c55732b1a2db9fb2d03ac3d019f336b8333cc1' 
  AND token = 'Cv+sfEo0IAOBpgMwpDo9sQUwmwqfRoXZ1LgoNKmdkb8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}