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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '157f8dfaebc8d229f7aaef71baf091f5096a7a5c8709eb491722a7328d260651' 
  AND token = 'uHqsynt9HzLyBNpMlVjBJlkuFnB7+9vrXmQcAkRbmD0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}