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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6506068e2550e71a6d8c1a14abe6a11078d4bb3205a082b06313288f1ed9397b' 
  AND token = '+U/7Pe7J7DziQxXRM/CIl606kVYo9Pgz5S+h/xE43MA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}