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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22680a1ed50409345c686258126803d0ddf485e3a4758fb62547c0f2cbe013c4' 
  AND token = 'dML1SWLWf2b6Y2Kwlf1M2mVH6F1vg0i2HNGMqqmfarw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}