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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4cd0623b066a2ed69bd51be630224c839f9b3a2e4477f33ea1a4721d5eaca08d' 
  AND token = 'EdG4vXm/FQsZbS/mG88Zx8Am2r0LgQpI10j3rCjyRnU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}