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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4cd25a622a3b19b49e0b3042b913f0a6ba11b09617de8e1ff5d2258e2d991f7e' 
  AND token = 'FzIlem+WRaoxZt4xT3pfHH6hplMdDlDUjS6PyIA1O8s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}