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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '468f88b75a0e93bb10fdda1e6392edb0768c338b82553aae63e7c348676e9c04' 
  AND token = '/fiDCxbeAnLUMg655oZ0O9RIFZhlSa2cZT4EkiFT4Eo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}