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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a650dff47397cf2432cad380bea750bcc43e86c86ab3bc85b951bac522f2d2f' 
  AND token = '6k9u66Tdl6dARSaUSARnj131Szgl2nWa18cQkse3XtE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}